Current Research Themes
Muti-scale Layered Control in Bacterial Cancer Immunotherapy
SPIKEs
We focus on engineering an intracellular non-model bacterial chassis that can sense disease-associated environments, activate therapeutic functions, and restrict its own growth. By coordinating payload delivery with population control and built-in containment, this work aims to make bacterial cancer therapy more precise, programmable, and safe.
Closed-loop Optogenetic Control in Multi-scale Dynamics
LEMOS
LEMOS enables closed-loop optogenetic control of gene expression in batch culture by integrating light-based actuation with real-time plate-reader measurements. This platform allows us to study and control multiscale biological dynamics as cells transition through growth phases, linking gene-circuit behavior, population growth, and feedback-control design.
Multi-scale Dynamic Model Development and Parameter Inference
GEAGS
GEAGS models synthetic gene circuits as multiscale systems shaped by molecular regulation, cellular growth, and resource allocation. We use this framework to design feedback control strategies that optimize resource utilization, modulate growth dynamics, and improve circuit stability.
Layered Stress Control for Space Bio-manufacturing
ARMOR
ARMOR uses layered stress control to support microbial biomanufacturing in space. The project combines stress-tolerance modules with optogenetic regulation so cells can survive orbital conditions while dynamically controlling growth and production.